Electron Paramagnetic Resonance Facility
in Life Sciences at the Chemistry-Biology interface
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Interests of EPR in Life Sciences
- Structural analysis at the atomic and molecular level of biological systems.
- Study of the function of complex redox enzymes.
- Protein dynamics.
- Protein-protein interactions.
Methodology
- Determination of the metal content.
- Analysis of metal cofactors.
- Detection of free radicals (oxidative stress, dosimetry, enzymatic mechanisms).
- Insertion of paramagnetic labels → Biostructural EPR.
Applications
- Microbial bioenergetic metabolism.
- Molecular sensitivity to stress factors (oxidative, thermal, chemical stress).
- Enzymatic engineering.
- Mapping molecular interactions between physiological partners.
- Study of structural transitions and folding / unfolding events.
- Organization of large biological assemblies.
- In-cell biostructural EPR.
Users
- Academics in Biology, Chemistry and Physics.
- Open to private companies.