Bioénergétique et Ingénierie des Protéines (BIP)
BIP – UMR 7281 (CNRS – AMU)
Bioénergétique et Ingénierie des Protéines (BIP)
EPR facility / Plateforme RPE
Electron Paramagnetic Resonance Facility
in Life Sciences at the Chemistry-Biology interface
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Interests of EPR in Life Sciences
Structural analysis at the atomic and molecular level of biological systems.
Study of the function of complex redox enzymes.
Protein dynamics.
Protein-protein interactions.
Methodology
Determination of the metal content.
Analysis of metal cofactors.
Detection of free radicals (oxidative stress, dosimetry, enzymatic mechanisms).
Insertion of paramagnetic labels → Biostructural EPR.
Applications
Microbial bioenergetic metabolism.
Molecular sensitivity to stress factors (oxidative, thermal, chemical stress).
Enzymatic engineering.
Mapping molecular interactions between physiological partners.
Study of structural transitions and folding / unfolding events.
Organization of large biological assemblies.
In-cell biostructural EPR.
Users
Academics in Biology, Chemistry and Physics.
Open to private companies.
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