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Chargée de Recherche, CNRS

+33 4 91 16 41 92

Equipe / Group: BIP 02

Keywords: Nuclear Magnetic Resonances, Conformational dynamics, Photosynthetic regulation, Microalgae, Intrinsically disordered protein, Redox regulation.

The regulation of the carbon cycle by microalgae is the focus of my research. In particular, the role of small dynamical regulatory proteins, their post-translational modification(s) and conformational transition(s) upon light-to-dark or light-to-dark transitions, under physiological conditions. Refer to our group page for details.

Researchgate: Launay Helene

ORCID id: 0000-0003-0639-2642


Hélène Launay, Wenmin Huang, Stephen C. Maberly, Brigitte Gontero.
Regulation of Carbon Metabolism by Environmental Conditions: A Perspective From Diatoms and Other Chromalveolates.
Front. Plant Sci., 2020, 11. DOI: 10.3389/fpls.2020.01033 HAL: hal-02903680v1


Marie Dujardin, Vanesa Madan, Neha S. Gandhi, François-Xavier Cantrelle, Hélène Launay, Isabelle Huvent, Ralf Bartenschlager, Guy Lippens, Xavier Hanoulle.
Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.
J. Biol. Chem., 2019, 70 (35), 3536 - 13185. DOI: 10.1074/jbc.RA119.009537 HAL: hal-02354947v1

Hélène Launay, Véronique Receveur-Bréchot, Frédéric Carrière, Brigitte Gontero.
Orchestration of algal metabolism by protein disorder.
Archives of Biochemistry and Biophysics, 2019, 672, 108070 -. DOI: 10.1016/j.abb.2019.108070 HAL: hal-02266032v1

Xiaolin Wang, John P. Kirkpatrick, Hélène M. M. Launay, Alfonso de Simone, Daniel Häussinger, Christopher M. Dobson, Michele Vendruscolo, Lisa D. Cabrita, Christopher A. Waudby, John Christodoulou.
Probing the dynamic stalk region of the ribosome using solution NMR.
Sci Rep, 2019, 10 (3), 1007 -. DOI: 10.1038/s41598-019-49190-1 HAL: hal-02466067v1


Hélène Launay, Patrick Barré, Carine Puppo, Yizhi Zhang, Stéphanie Maneville, Brigitte Gontero, Véronique Receveur-Bréchot.
Cryptic Disorder Out of Disorder: Encounter between Conditionally Disordered CP12 and Glyceraldehyde-3-Phosphate Dehydrogenase.
Journal of Molecular Biology, 2018, 430 (8), 1218 - 1234. DOI: 10.1016/j.jmb.2018.02.020 HAL: hal-01794097v1

Yizhi Zhang, Hélène Launay, Antoine Schramm, Régine Lebrun, Brigitte Gontero.
Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii.
Sci Rep, 2018, 28 (1), 235 -. DOI: 10.1038/s41598-018-24772-7 HAL: hal-01794065v1

Yizhi Zhang, Hélène Launay, Fan Liu, Régine Lebrun, Brigitte Gontero.
Interaction between adenylate kinase 3 and glyceraldehyde‐3‐phosphate dehydrogenase from Chlamydomonas reinhardtii.
FEBS J, 2018, 197 (13), 791 - 2503. DOI: 10.1111/febs.14494 HAL: hal-01833991v1


Luiza M. Bessa, Hélène Launay, Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Isabelle Landrieu, Robert Schneider, Xavier Hanoulle.
NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
J. Biol. Chem., 2017, 8 (44), 796 - 18043. DOI: 10.1074/jbc.M117.813766 HAL: hal-01620117v1


Anaïs M E Cassaignau, Hélène M M Launay, Maria-Evangelia Karyadi, Xiaolin Wang, Christopher A Waudby, Annika Deckert, Amy L Robertson, John Christodoulou, Lisa D Cabrita.
A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy.
Nat Protoc, 2016, 219 (8), 46 - 1507. DOI: 10.1038/nprot.2016.101

Lisa D Cabrita, Anaïs M E Cassaignau, Hélène M M Launay, Christopher A Waudby, Tomasz Wlodarski, Carlo Camilloni, Maria-Evangelia Karyadi, Amy L Robertson, Xiaolin Wang, Anne S Wentink, Luke S Goodsell, Cheryl A Woolhead, Michele Vendruscolo, Christopher M Dobson, John Christodoulou.
A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding.
Nat Struct Mol Biol, 2016, 126 (4), 014101 - 285. DOI: 10.1038/nsmb.3182

Hélène Launay, Patrick Barré, Carine Puppo, Stéphanie Manneville, Brigitte Gontero, Véronique Receveur-Bréchot.
Absence of residual structure in the intrinsically disordered regulatory protein CP12 in its reduced state.
Biochemical and Biophysical Research Communications, 2016, 477 (1), 20 - 26. DOI: 10.1016/j.bbrc.2016.06.014 HAL: hal-01430932v1


Marie Dujardin, Vanesa Madan, Roland Montserret, Puneet Ahuja, Isabelle Huvent, Helene Launay, Arnaud Leroy, Ralf Bartenschlager, François Penin, Guy Lippens, Xavier Hanoulle.
A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication.
J. Biol. Chem., 2015, 71 (31), 2107 - 19120. DOI: 10.1074/jbc.M115.644419 HAL: hal-01221930v1


Fabian Blombach, Helene Launay, Ambrosius P. L. Snijders, Violeta Zorraquino, Hao Wu, Bart de Koning, Stan J. J. Brouns, Thijs J. G. Ettema, Carlo Camilloni, Andrea Cavalli, Michele Vendruscolo, Mark J. Dickman, Lisa D. Cabrita, Anna La Teana, Dario Benelli, Paola Londei, John Christodoulou, John van der Oost.
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix–turn–helix domain.
2014, 214 (2), 48 - 384. DOI: 10.1042/BJ20131474


Helene Launay, Benjamin Parent, Adeline Page, Xavier Hanoulle, Guy Lippens.
Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement.
Angew. Chem. Int. Ed., 2013, 6 (48), 277 - 12591. DOI: 10.1002/anie.201306253 HAL: hal-00903363v1

Caroline Smet-Nocca, Hélène Launay, Jean-Michel Wieruszeski, Guy Lippens, Isabelle Landrieu.
Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.
J Biomol NMR, 2013, 278 (5345), 1957 - 337. DOI: 10.1007/s10858-013-9716-z HAL: hal-00903359v1


Claire Rosnoblet, Bernd Fritzinger, Dominique Legrand, Hélène Launay, Jean-Michel Wieruszeski, Guy Lippens, Xavier Hanoulle.
Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A.
J. Biol. Chem., 2012, 3 (53), 39 - 44260. DOI: 10.1074/jbc.M112.392209 HAL: hal-00765873v1


F. Blombach, H. Launay, V. Zorraquino, D. C. Swarts, L. D. Cabrita, D. Benelli, J. Christodoulou, P. Londei, J. van der Oost.
An HflX-Type GTPase from Sulfolobus solfataricus Binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States.
Journal of Bacteriology, 2011, 322 (51), 565 - 2867. DOI: 10.1128/JB.01552-10


Lisa D. Cabrita, Shang-Te Danny Hsu, Helene Launay, Christopher M. Dobson, John Christodoulou.
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.
PNAS, 2009, 106 (52), 22239 - 22244. DOI: 10.1073/pnas.0903750106


S.-T. D. Hsu, P. Fucini, L. D. Cabrita, H. Launay, C. M. Dobson, J. Christodoulou.
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.
Proceedings of the National Academy of Sciences, 2007, 6 (3), 277 - 16521. DOI: 10.1073/pnas.0704664104