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Chargée de Recherche, CNRS

+33 4 91 16 46 72

Equipe / Group: BIP 09

25 years of work on the same enzyme, and plans for the 15 years to come – this may sound like an obsession. What is so special about the Rieske/cytb complex to keep me busy for decades?
Rieske/cytb complexes are part of most bioenergetics reaction chains. They accept electrons from the quinone pool and transfer them to a terminal oxidase. Whatever quinone reductase and terminal oxidase there are, you will nearly always find the Rieske/cytb as the third party and this ever since the common ancestor of all living beings.
Working with the Rieske/cytb complex is therefore like travelling with a faithful companion: it takes you to a stroll across biodiversity, makes you meet many different metabolisms and allows a time-travel back to the Last Universal Common Ancestor.
Like photos in a family album I sample members of the Rieske/cytb enzyme family on this journey, trace down their common threads to conclude on the essentials empowering function while marveling at their diversity, thereby exploring a wide range of adaptations and interactions with their metabolic environment.

Keywords: Rieske/cytb complex, bc1 complex, b6f complex, heme ci, electron bifurcation, anammox metabolism, evolution of bioenergetics

ORCID id: 0000-0002-2612-4939


Simon Duval, Kilian Zuchan, Frauke Baymann, Barbara Schoepp-Cothenet, Elbert Branscomb, Michael J. Russell, Wolfgang Nitschke.
Minerals and the emergence of life.
MILS, Metals, Microbes, and Minerals - The Biogeochemical Side of Life, 2021, 21, 135-157. DOI: 10.1515/9783110589771-011 HAL: hal-03163239v1

Kilian Zuchan, Frauke Baymann, Carole Baffert, Myriam Brugna, Wolfgang Nitschke.
The dyad of the Y-junction- and a flavin module unites diverse redox enzymes.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2021, 1862 (6), 148401 -. DOI: 10.1016/j.bbabio.2021.148401


Christina Ferousi, Simon Lindhoud, Frauke Baymann, Eric R. Hester, Joachim Reimann, Boran Kartal.
Discovery of a functional, contracted heme-binding motif within a multiheme cytochrome.
J. Biol. Chem., 2019, 261 (45), 1126 - 16965. DOI: 10.1074/jbc.RA119.010568 HAL: hal-02369902v1

Magda Grabsztunowicz, Paula Mulo, Frauke Baymann, Risa Mutoh, Genji Kurisu, Pierre Sétif, Peter Beyer, Anja Krieger‐Liszkay.
Electron transport pathways in isolated chromoplasts from Narcissus pseudonarcissus L..
Plant J, 2019, 90, 4145 -. DOI: 10.1111/tpj.14319 HAL: hal-02397878v1

Simon Duval, Frauke Baymann, Barbara Schoepp-Cothenet, Fabienne Trolard, Guilhem Bourrié, Olivier Grauby, Elbert Branscomb, Michael J. Russell, Wolfgang Nitschke.
Fougerite: the not so simple progenitor of the first cells.
Interface Focus, 2019, 323 (6), 93 -. DOI: 10.1098/rsfs.2019.0063 HAL: hal-02359667v1


Frauke Baymann, Barbara Schoepp-Cothenet, Simon Duval, Marianne Guiral, Myriam Brugna, Carole Baffert, Michael J. Russell, Wolfgang Nitschke.
On the Natural History of Flavin-Based Electron Bifurcation.
Front. Microbiol., 2018, 8, 357 -. DOI: 10.3389/fmicb.2018.01357 HAL: hal-01828959v1


Christina Ferousi, Simon Lindhoud, Frauke Baymann, Boran Kartal, Mike SM Jetten, Joachim Reimann.
Iron assimilation and utilization in anaerobic ammonium oxidizing bacteria.
Current Opinion in Chemical Biology, 2017, 37, 129 - 136. DOI: 10.1016/j.cbpa.2017.03.009 HAL: hal-01501483v1


Lucie Bergdoll, Felix ten Brink, Wolfgang Nitschke, Daniel Picot, Frauke Baymann.
From low- to high-potential bioenergetic chains: Thermodynamic constraints of Q-cycle function.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016, 1857 (9), 1569 - 1579. DOI: 10.1016/j.bbabio.2016.06.006 HAL: hal-01413250v1

Sebastian Veit, Kazuki Takeda, Yuichi Tsunoyama, Frauke Baymann, Reinat Nevo, Ziv Reich, Matthias Rögner, Kunio Miki, Sascha Rexroth.
Structural and functional characterisation of the cyanobacterial PetC3 Rieske protein family.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016, 1857 (12), 1879 - 1891. DOI: 10.1016/j.bbabio.2016.09.007 HAL: hal-01441855v1

Sebastian Glatt, Rene Zabel, Olga Kolaj-Robin, Osita F Onuma, Florence Baudin, Andrea Graziadei, Valerio Taverniti, Ting-Yu Lin, Frauke Baymann, Bertrand Séraphin, Karin D Breunig, Christoph W Müller.
Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.
Nat Struct Mol Biol, 2016, 45 (10B), 342 - 802. DOI: 10.1038/nsmb.3265 HAL: hal-01413474v1

Wei-Chun Kao, Thomas Kleinschroth, Wolfgang Nitschke, Frauke Baymann, Yashvin Neehaul, Petra Hellwig, Sebastian Richers, Janet Vonck, Michael Bott, Carola Hunte.
The obligate respiratory supercomplex from Actinobacteria.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016, 1857 (10), 1705 - 1714. DOI: 10.1016/j.bbabio.2016.07.009 HAL: hal-01415865v1


Anne-Lise Ducluzeau, Barbara Schoepp-Cothenet, Frauke Baymann, Michael J. Russell, Wolfgang Nitschke.
Free energy conversion in the LUCA: Quo vadis?.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014, 1837 (7), 982 - 988. DOI: 10.1016/j.bbabio.2013.12.005 HAL: hal-01493447v1

Anne-Lise Ducluzeau, Barbara Schoepp-Cothenet, Robert van Lis, Frauke Baymann, Michael J. Russell, Wolfgang Nitschke.
The evolution of respiratory O 2 /NO reductases: an out-of-the-phylogenetic-box perspective.
J. R. Soc. Interface, 2014, 265 (98), 11 535 -. DOI: 10.1098/rsif.2014.0196 HAL: hal-01494539v1


Olga Kolaj-Robin, Mohamed R. Noor, Sarah R. O’Kane, Frauke Baymann, Tewfik Soulimane.
Atypical Features of Thermus thermophilus Succinate:Quinone Reductase.
PLoS ONE, 2013, 43 (1), 1441 -. DOI: 10.1371/journal.pone.0053559

F. ten Brink, B. Schoepp-Cothenet, R. van Lis, W. Nitschke, F. Baymann.
Multiple Rieske/cytb complexes in a single organism.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2013, 1827 (11-12), 1392 - 1406. DOI: 10.1016/j.bbabio.2013.03.003 HAL: hal-01607947v1

Barbara Schoepp-Cothenet, Robert van Lis, Ariane Atteia, Frauke Baymann, Line Capowiez, Anne-Lise Ducluzeau, Simon Duval, Felix ten Brink, Michael J. Russell, Wolfgang Nitschke.
On the universal core of bioenergetics.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2013, 1827 (2), 79 - 93. DOI: 10.1016/j.bbabio.2012.09.005 HAL: hal-01606377v1


Frauke Baymann, Barbara Schoepp-Cothenet, Evelyne Lebrun, Robert van Lis, Wolfgang Nitschke.
Phylogeny of Rieske/cytb Complexes with a Special Focus on the Haloarchaeal Enzymes.
2012, 392 (8), 677 - 841. DOI: 10.1093/gbe/evs056 HAL: hal-01607945v1


Olga Kolaj-Robin, Sarah R. O'Kane, Wolfgang Nitschke, Christophe Léger, Frauke Baymann, Tewfik Soulimane.
Biochemical and biophysical characterization of succinate: Quinone reductase from Thermus thermophilus.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011, 1807 (1), 68 - 79. DOI: 10.1016/j.bbabio.2010.10.009 HAL: hal-00999887v1


F. Baymann, W. Nitschke.
Heliobacterial Rieske/cytb complex.
Photosynth Res, 2010, 90 (2-3), 4145 - 187. DOI: 10.1007/s11120-009-9524-1

W. Nitschke, R. van Lis, B. Schoepp-Cothenet, F. Baymann.
The “green” phylogenetic clade of Rieske/cytb complexes.
Photosynth Res, 2010, 128 (2-3), 14246 - 355. DOI: 10.1007/s11120-010-9532-1 HAL: hal-01607249v1


B. Schoepp-Cothenet, C. Lieutaud, F. Baymann, A. Vermeglio, T. Friedrich, D. M. Kramer, W. Nitschke.
Menaquinone as pool quinone in a purple bacterium.
Proceedings of the National Academy of Sciences, 2009, 5 (3), 151 - 8554. DOI: 10.1073/pnas.0813173106


A.L. Ducluzeau, E. Chenu, L. Capowiez, F. Baymann.
The Rieske/cytochrome b complex of Heliobacteria.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008, 1777 (9), 1140 - 1146. DOI: 10.1016/j.bbabio.2008.04.026


F. Baymann, F. Giusti, D. Picot, W. Nitschke.
The ci/bH moiety in the b6f complex studied by EPR: A pair of strongly interacting hemes.
Proceedings of the National Academy of Sciences, 2007, 1100 (1), 128 - 524. DOI: 10.1073/pnas.0606369104 HAL: hal-02329862v1


Evelyne Lebrun, Joanne M. Santini, Myriam Brugna, Anne-Lise Ducluzeau, Soufian Ouchane, Barbara Schoepp-Cothenet, Frauke Baymann, Wolfgang Nitschke.
The Rieske Protein: A Case Study on the Pitfalls of Multiple Sequence Alignments and Phylogenetic Reconstruction.
2006, 23 (6), 1180 - 1191. DOI: 10.1093/molbev/msk010 HAL: hal-00132690v1


F. Baymann, E. Lebrun, W. Nitschke.
Mitochondrial cytochrome c1 is a collapsed di-heme cytochrome.
Proceedings of the National Academy of Sciences, 2004, 179 (5), 1734 - 17740. DOI: 10.1073/pnas.0407442101


E. Lebrun, M. Brugna, F. Baymann, D. Muller, D. Lievremont, M.-C. Lett, W. Nitschke.
Arsenite Oxidase, an Ancient Bioenergetic Enzyme.
2003, 20 (5), 686 - 693. DOI: 10.1093/molbev/msg071 HAL: hal-00113712v1

Michael Schütz, Barbara Schoepp-Cothenet, Elisabeth Lojou, Mireille Woodstra, Doris Lexa, Pascale Tron, Alain Dolla, Marie-Claire Durand, Karl Otto Stetter, Frauke Baymann.
The Naphthoquinol Oxidizing Cytochrome bc 1 Complex of the Hyperthermophilic Knallgasbacterium Aquifex aeolicus : Properties and Phylogenetic Relationships †.
Biochemistry, 2003, 42 (36), 10800 - 10808. DOI: 10.1021/bi034452a

Frauke Baymann, Evelyne Lebrun, Myriam Brugna, Barbara Schoepp–Cothenet, Marie–Thérèse Giudici–Orticoni, Wolfgang Nitschke.
The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes.
Phil. Trans. R. Soc. Lond. B, 2003, 180 (1429), 1460 - 274. DOI: 10.1098/rstb.2002.1184 HAL: hal-00343715v1

Frauke Baymann, Nicola L Barlow, Corinne Aubert, Barbara Schoepp-Cothenet, Gisele Leroy, Fraser A Armstrong.
Voltammetry of a ‘protein on a rope’.
2003, 9 (1-3), 48 - 94. DOI: 10.1016/S0014-5793(03)00206-0


Frauke Baymann, Pascale Tron, Barbara Schoepp-Cothenet, Corinne Aubert, Pierre Bianco, Karl-Otto Stetter, Wolfgang Nitschke, Michael Schütz.
Cytochromes c 555 from the Hyperthermophilic Bacterium Aquifex aeolicus (VF5). 1. Characterization of Two Highly Homologous, Soluble and Membranous, Cytochromes.
Biochemistry, 2001, 40 (45), 13681 - 13689. DOI: 10.1021/bi011201y

Frauke Baymann, Myriam Brugna, Ulrich Mühlenhoff, Wolfgang Nitschke.
Daddy, where did (PS)I come from?.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001, 1507 (1-3), 291 - 310. DOI: 10.1016/S0005-2728(01)00209-2

Frauke Baymann, Fabrice Rappaport, Pierre Joliot, Toivo Kallas.
Rapid Electron Transfer to Photosystem I and Unusual Spectral Features of Cytochrome c 6 in Synechococcus sp. PCC 7002 in Vivo †.
Biochemistry, 2001, 40 (35), 10570 - 10577. DOI: 10.1021/bi010194a

Barbara Schoepp-Cothenet, Michael Schütz, Frauke Baymann, Myriam Brugna, Wolfgang Nitschke, Hannu Myllykallio, Christian Schmidt.
The membrane-extrinsic domain of cytochrome b 558/566 from the Archaeon Sulfolobus acidocaldarius performs pivoting movements with respect to the membrane surface.
2001, 16 (3), 544 - 376. DOI: 10.1016/S0014-5793(00)02357-7


Michael Schütz, Myriam Brugna, Evelyne Lebrun, Frauke Baymann, Robert Huber, Karl-Otto Stetter, Günter Hauska, René Toci, Danielle Lemesle-Meunier, Pascale Tron, Christian Schmidt, Wolfgang Nitschke.
Early Evolution of Cytochrome bc Complexes.
Journal of Molecular Biology, 2000, 300 (4), 663 - 675. DOI: 10.1006/jmbi.2000.3915


Franke Baymann, Francesca Zito, Richard Kuras, Limor Minai, Wolfgang Nitschke, Francis-André Wollman.
Functional Characterization of Chlamydomonas Mutants Defective in Cytochrome f Maturation.
J. Biol. Chem., 1999, 3 (33), 243 - 22967. DOI: 10.1074/jbc.274.33.22957