Goetz PARSIEGLA

member photo

Maître de Conférences, Aix-Marseille Université

+33 4 91 16 41 92

Equipe / Group: BIP 02


Keywords: Structural biology, structural Enzymology, Lipases, Glycosyl-hydrolases, in silico Docking and structural Modelling

Structural biologist specialized in 3D protein structure interpretation and structural bioinformatics. Mainly working on Lipases/Galactolipases/Phospholipases and Glycosyl-hydrolases involved in Biomass conversion and digestion. Interested in microalgal Biomass generation and its applications.
In charge of the organization of the 3rd year of the Department of biological engineering at Polytech Marseille for more than 10 years and project leader of pedagogy and innovation at Polytech Marseille since 2017.


Publications

2020

Nabil Smichi, Goetz Parsiegla, Neila Achouri, Zied Zarai, Abdelkarim Abousalham, Ahmed Fendri.
Intestinal phospholipase A2 from Sparidae species: Functional properties and cytotoxic potential evaluation.
International Journal of Biological Macromolecules, 2020, 143, 881 - 890. DOI: 10.1016/j.ijbiomac.2019.09.149 HAL: hal-02466102v1

Moulay Sahaka, Sawsan Amara, Jutarat Wattanakul, Mohamed A. Gedi, Noelia Aldai, Goetz Parsiegla, Jérôme Lecomte, John T. Christeller, David Gray, Brigitte Gontero, Pierre Villeneuve, Frédéric Carrière.
The digestion of galactolipids and its ubiquitous function in Nature for the uptake of the essential α-linolenic acid.
Food Funct., 2020. DOI: 10.1039/D0FO01040E HAL: hal-02903683v1



2019

Nian Liu, Aurélie Fosses, Clara Kampik, Goetz Parsiegla, Yann Denis, Nicolas Vita, Henri-Pierre Fierobe, Stéphanie Perret.
In vitro and in vivo exploration of the cellobiose and cellodextrin phosphorylases panel in Ruminiclostridium cellulolyticum: implication for cellulose catabolism.
Biotechnol Biofuels, 2019, 42 (Web server issu), W320 -. DOI: 10.1186/s13068-019-1549-x HAL: hal-02312679v1



2018

Najeh Krayem, Goetz Parsiegla, Hélène Gaussier, Hanen Louati, Raida Jallouli, Pascal Mansuelle, Frédéric Carrière, Youssef Gargouri.
Functional characterization and FTIR-based 3D modeling of full length and truncated forms of Scorpio maurus venom phospholipase A 2.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862 (5), 1247 - 1261. DOI: 10.1016/j.bbagen.2018.02.004 HAL: hal-01739569v1

Inès Belhaj, Sawsan Amara, Goetz Parsiegla, Priscila Sutto-Ortiz, Moulay Sahaka, Hafedh Belghith, Audric Rousset, Dominique Lafont, Frédéric Carrière.
Galactolipase activity of Talaromyces thermophilus lipase on galactolipid micelles, monomolecular films and UV-absorbing surface-coated substrate.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018, 1863 (9), 1006 - 1015. DOI: 10.1016/j.bbalip.2018.05.016 HAL: hal-01819569v1



2017

Raida Jallouli, Goetz Parsiegla, Frédéric Carrière, Youssef Gargouri, Sofiane Bezzine.
Efficient heterologous expression of Fusarium solani lipase, FSL2, in Pichia pastoris, functional characterization of the recombinant enzyme and molecular modeling.
International Journal of Biological Macromolecules, 2017, 94, 61 - 71. DOI: 10.1016/j.ijbiomac.2016.09.030



2015

Jannet Kamoun, Mathieu Schué, Wala Messaoud, Justine Baignol, Vanessa Point, Eduardo Mateos-Diaz, Pascal Mansuelle, Youssef Gargouri, Goetz Parsiegla, Jean-François Cavalier, Frédéric Carrière, Ahmed Aloulou.
Biochemical characterization of Yarrowia lipolytica LIP8, a secreted lipase with a cleavable C-terminal region.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015, 1851 (2), 129 - 140. DOI: 10.1016/j.bbalip.2014.10.012

Raida Jallouli, Houcemeddine Othman, Sawsan Amara, Goetz Parsiegla, Frédéric Carriere, Najet Srairi-abid, Youssef Gargouri, Sofiane Bezzine.
The galactolipase activity of Fusarium solani (phospho)lipase.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015, 1851 (3), 282 - 289. DOI: 10.1016/j.bbalip.2014.12.010



2013

Vanessa Point, Anaïs Bénarouche, Ikram Jemel, Goetz Parsiegla, Gérard Lambeau, Frédéric Carrière, Jean-François Cavalier.
Effects of the propeptide of group X secreted phospholipase A2 on substrate specificity and interfacial activity on phospholipid monolayers.
Biochimie, 2013, 95 (1), 51 - 58. DOI: 10.1016/j.biochi.2012.07.023

Anaïs Bénarouche, Vanessa Point, Goetz Parsiegla, Frédéric Carrière, Jean-François Cavalier.
New insights into the pH-dependent interfacial adsorption of dog gastric lipase using the monolayer technique.
Colloids and Surfaces B: Biointerfaces, 2013, 111, 306 - 312. DOI: 10.1016/j.colsurfb.2013.06.025

Sawsan Amara, Dominique Lafont, Goetz Parsiegla, Vanessa Point, Aurélie Chabannes, Audric Rousset, Frédéric Carrière.
The galactolipase activity of some microbial lipases and pancreatic enzymes.
Eur. J. Lipid Sci. Technol., 2013, 1771 (4), 1446 - 451. DOI: 10.1002/ejlt.201300004



2012

Vanessa Point, K.V.P. Pavan Kumar, Sylvain Marc, Vincent Delorme, Goetz Parsiegla, Sawsan Amara, Frédéric Carrière, Gérard Buono, Frédéric Fotiadu, Stéphane Canaan, Julien Leclaire, Jean-François Cavalier.
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones.
European Journal of Medicinal Chemistry, 2012, 58, 452 - 463. DOI: 10.1016/j.ejmech.2012.10.040 HAL: hal-00726237v1

Goetz Parsiegla, Bindesh Shrestha, Frédéric Carrière, Akos Vertes.
Direct Analysis of Phycobilisomal Antenna Proteins and Metabolites in Small Cyanobacterial Populations by Laser Ablation Electrospray Ionization Mass Spectrometry.
Anal. Chem., 2012, 84 (1), 34 - 38. DOI: 10.1021/ac202831w

Goetz Parsiegla, Christophe Noguere, Lydia Santell, Robert A. Lazarus, Yves Bourne.
The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-like Superfamily.
Biochemistry, 2012, 51 (51), 10250 - 10258. DOI: 10.1021/bi300873f



2008

Goetz Parsiegla, Corinne Reverbel, Chantal Tardif, Hugues Driguez, Richard Haser.
Structures of Mutants of Cellulase Cel48F of Clostridium cellulolyticum in Complex with Long Hemithiocellooligosaccharides Give Rise to a New View of the Substrate Pathway during Processive Action.
Journal of Molecular Biology, 2008, 375 (2), 499 - 510. DOI: 10.1016/j.jmb.2007.10.039 HAL: hal-00166258v1



2006

Isabelle Benoit, Michèle Asther, Gerlind Sulzenbacher, Eric Record, Laurence Marmuse, Goetz Parsiegla, Isabelle Gimbert, Marcel Asther, Christophe Bignon.
Respective importance of protein folding and glycosylation in the thermal stability of recombinant feruloyl esterase A.
2006, 580 (25), 5815 - 5821. DOI: 10.1016/j.febslet.2006.09.039