Directrice de Recherche, HDR, CNRS
+33 4 91 16 44 55
Equipe / Group: BIP 07
My research work on metalloproteins seeks to understand the molecular aspects of the various biologically-competent catalytic pathways in heme-containing proteins. The identification of redox-active Trp and Tyr radicals and the characterization of their role(s) in electron transfer and concerted reactivity with the heme cofactor in enzyme catalysis, is of particular interest. The aim is to unveil Nature’s specific strategies to selectively fine tune the reactivity of Trp and Tyr as oxidation sites and/or electron relays in enzyme catalysis. Such fundamental and detailed knowledge is necessary to better exploit heme-containing proteins as natural catalysts, and ultimately design and develop bioinspired artificial mini-proteins, as tunable catalysts to be used in chemical and pharmaceutical industrial applications. Accordingly, our work includes both natural and synthetic heme catalysts.
ORCID id: 0000-0002-4275-0980
Karl J. Koebke, Toni Kühl, Elisabeth Lojou, Borries Demeler, Barbara Schoepp-Cothenet, Olga Iranzo, Vincent L. Pecoraro, Anabella Ivancich.
The pH‐Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial α‐Helical Metalloprotein.
Angew. Chem. Int. Ed., 2021, 60 (8), 3974 - 3978. DOI: 10.1002/anie.202012673 HAL: hal-03017501
Sarmistha Bhunia, Atanu Rana, Somdatta Ghosh Dey, Anabella Ivancich, Abhishek Dey.
A designed second-sphere hydrogen-bond interaction that critically influences the O–O bond activation for heterolytic cleavage in ferric iron–porphyrin complexes.
Chem. Sci., 2020, 11 (10), 2681 - 2695. DOI: 10.1039/C9SC04388H HAL: hal-02887080v1
Anabella Ivancich, Peter C. Loewen.
Electron Transfer in Catalases and Catalase-Peroxidases.
Encyclopedia of Biophysics, European Biophysical Societies’ Association (EBSA), (Roberts G., Watts A., Eds). Springer, Berlin, Heidelberg., 2018. DOI: 10.1007/978-3-642-35943-9_51-1 HAL: hal-01798212v1
Yannick H. Ouellet, Cheikh Tidiane Ndiaye, Stéphane M. Gagné, Anne Sebilo, Michael D.L. Suits, Éric Jubinville, Zongchao Jia, Anabella Ivancich, Manon Couture.
An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).
Journal of Inorganic Biochemistry, 2016, 154, 103 - 113. DOI: 10.1016/j.jinorgbio.2015.11.002 HAL: hal-01406050v1
Peter C. Loewen, Jacylyn Villanueva, Jacek Switala, Lynda J. Donald, Anabella Ivancich.
Unprecedented access of phenolic substrates to the heme active site of a catalase: Substrate binding and peroxidase-like reactivity of Bacillus pumilus catalase monitored by X-ray crystallography and EPR spectroscopy.
Proteins, 2015, 83 (5), 853 - 866. DOI: 10.1002/prot.24777 HAL: hal-01432180v1
Arianna I. Celis, Zachary Geeraerts, David Ngmenterebo, Melodie M. Machovina, Richard C. Kurker, Kumar Rajakumar, Anabella Ivancich, Kenton R. Rodgers, Gudrun S. Lukat-Rodgers, Jennifer L. DuBois.
A Dimeric Chlorite Dismutase Exhibits O 2 -Generating Activity and Acts as a Chlorite Antioxidant in Klebsiella pneumoniae MGH 78578.
Biochemistry, 2015, 54 (2), 434 - 446. DOI: 10.1021/bi501184c HAL: hal-01432151v1
Kyle D. Miner, Thomas D. Pfister, Parisa Hosseinzadeh, Nadime Karaduman, Lynda J. Donald, Peter C. Loewen, Yi Lu, Anabella Ivancich.
Identifying the Elusive Sites of Tyrosyl Radicals in Cytochrome c Peroxidase: Implications for Oxidation of Substrates Bound at a Site Remote from the Heme.
Biochemistry, 2014, 53 (23), 3781 - 3789. DOI: 10.1021/bi500353p HAL: hal-01556875v1
Jacylyn Villanueva, Jack Switala, Anabella Ivancich, Peter C. Loewen.
Genome Sequence of Bacillus pumilus MTCC B6033.
Genome Announcements, 2014, 2 (2), 1-2. DOI: 10.1128/genomeA.00327-14 HAL: hal-02885676v1