Maître de Conférence, Aix-Marseille Université
+33 4 91 16 45 68
Chef d'équipe / Group leader: BIP 05
Publications
2023
Andrea Fasano, Chloé Guendon, Aurore Jacq-Bailly, Arlette Kpebe, Jérémy Wozniak, Carole Baffert, Melisa del Barrio, Vincent Fourmond, Myriam Brugna, Christophe Léger.
A Chimeric NiFe Hydrogenase Heterodimer to Assess the Role of the Electron Transfer Chain in Tuning the Enzyme’s Catalytic Bias and Oxygen Tolerance.
J. Am. Chem. Soc., 2023.
DOI: 10.1021/jacs.3c06895
Anna Aldinio-Colbachini, Andrea Fasano, Chloé Guendon, Aurore Bailly, Jeremy Wozniak, Carole Baffert, Arlette Kpebe, Christophe Léger, Myriam Brugna, Vincent Fourmond.
Transport limited adsorption experiments give a new lower estimate of the turnover frequency of Escherichia coli hydrogenase 1.
BBA Advances, 2023, 100090 -.
DOI: 10.1016/j.bbadva.2023.100090
HAL: hal-04221197
Kpebe A., Guendon C., Payne N., Ros J., Berbar M.K., Lebrun R, Baffert C., Shintu L., Brugna M.
An essential role of the reversible electron-bifurcating hydrogenase Hnd for ethanol oxidation in Solidesulfovibrio fructosivorans..
Front. Microbiol., 2023, 14.
DOI: 10.3389/fmicb.2023.1139276
Natalie Payne, Arlette Kpebe, Chloé Guendon, Carole Baffert, Matthieu Maillot, Typhaine Haurogné, Fabrice Tranchida, Myriam Brugna, Laetitia Shintu.
NMR-based metabolomic analysis of the physiological role of the electron-bifurcating FeFe-hydrogenase Hnd in Solidesulfovibrio fructosivorans under pyruvate fermentation.
Microbiological Research, 2023, 268, 127279.
DOI: 10.1016/j.micres.2022.127279
2022
Natalie Payne, Arlette Kpebe, Chloé Guendon, Carole Baffert, Julien Ros, Régine Lebrun, Yann Denis, Laetitia Shintu, Myriam Brugna.
The electron-bifurcating FeFe-hydrogenase Hnd is involved in ethanol metabolism in Desulfovibrio fructosovorans grown on pyruvate.
Mol Microbiol, 2022, 117 (4), 907-920.
DOI: doi: 10.1111/mmi.14881
HAL: hal-03548887
Arlette Kpebe, Stéphane Grimaldi, Myriam Brugna, Eric Pilet.
First steps in the characterization of cytochrome bd oxidase from Solidesulfovibrio fructosovorans.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2022, 1863, 148691.
DOI: 10.1016/j.bbabio.2022.148691
2021
Kilian Zuchan, Frauke Baymann, Carole Baffert, Myriam Brugna, Wolfgang Nitschke.
The dyad of the Y-junction- and a flavin module unites diverse redox enzymes.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2021, 1862 (6), 148401 -.
DOI: 10.1016/j.bbabio.2021.148401
HAL: hal-03169066v1
Aurore Jacq-Bailly, Martino Benvenuti, Natalie Payne, Arlette Kpebe, Christina Felbek, Vincent Fourmond, Christophe Léger, Myriam Brugna, Carole Baffert.
Electrochemical Characterization of a Complex FeFe Hydrogenase, the Electron-Bifurcating Hnd From Desulfovibrio fructosovorans.
Front. Chem., 2021, 8.
DOI: 10.3389/fchem.2020.573305
HAL: hal-03103487v1
2020
Baptiste Roumezi, Luisana Avilan, Véronique Risoul, Myriam Brugna, Sophie Rabouille, Amel Latifi.
Overproduction of the Flv3B flavodiiron, enhances the photobiological hydrogen production by the nitrogen-fixing cyanobacterium Nostoc PCC 7120.
Microb Cell Fact, 2020, 19 (1).
DOI: 10.1186/s12934-020-01320-5
HAL: hal-02539734
2019
Melisa del Barrio, Chloé Guendon, Arlette Kpebe, Carole Baffert, Vincent Fourmond, Myriam Brugna, Christophe Léger.
Valine-to-Cysteine Mutation Further Increases the Oxygen Tolerance of Escherichia coli NiFe Hydrogenase Hyd-1.
ACS Catal., 2019, 9 (5), 4084 - 4088.
DOI: 10.1021/acscatal.9b00543
HAL: hal-02104593v1
Carole Baffert, Arlette Kpebe, Luisana Avilan, Myriam Brugna.
Hydrogenases and H2 metabolism in sulfate-reducing bacteria of the Desulfovibrio genus..
Advances in Microbial Physiology., 2019, 74, 143 - 189.
DOI: 10.1016/bs.ampbs.2019.03.001
HAL: hal-02180360
Amel Latifi, Luisana Avilan, Myriam Brugna.
Clostridial whole cell and enzyme systems for hydrogen production: current state and perspectives.
Appl Microbiol Biotechnol, 2019, 196 (22), 567 - 575.
DOI: 10.1007/s00253-018-9514-3
HAL: hal-01928533v1
2018
Arlette Kpebe, Martino Benvenuti, Chloé Guendon, Amani Rebai, Victoria Fernandez, Sébastien Le Laz, Emilien Etienne, Bruno Guigliarelli, Gabriel García-Molina, Antonio L. de Lacey, Carole Baffert, Myriam Brugna.
A new mechanistic model for an O2-protected electron-bifurcating hydrogenase, Hnd from Desulfovibrio fructosovorans.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2018, 1859 (12), 1302 - 1312.
DOI: 10.1016/j.bbabio.2018.09.364
HAL: hal-01928576v1
Frauke Baymann, Barbara Schoepp-Cothenet, Simon Duval, Marianne Guiral, Myriam Brugna, Carole Baffert, Michael J. Russell, Wolfgang Nitschke.
On the Natural History of Flavin-Based Electron Bifurcation.
Front. Microbiol., 2018, 8, 357 -.
DOI: 10.3389/fmicb.2018.01357
HAL: hal-01828959v1
Luisana Avilan, Baptiste Roumezi, Véronique Risoul, Christophe Sébastien Bernard, Arlette Kpebe, Mayssène Belhadjhassine, Marc Rousset, Myriam Brugna, Amel Latifi.
Phototrophic hydrogen production from a clostridial [FeFe] hydrogenase expressed in the heterocysts of the cyanobacterium Nostoc PCC 7120.
Appl Microbiol Biotechnol, 2018, 66 (5), 1219 - 5783.
DOI: 10.1007/s00253-018-8989-2
HAL: hal-02353976v1
2016
Sébastien Le Laz, Arlette kpebe, Marielle Bauzan, Sabrina Lignon, Marc Rousset, Myriam Brugna.
Expression of terminal oxidases under nutrient-starved conditions in Shewanella oneidensis: detection of the A-type cytochrome c oxidase.
Sci Rep, 2016, 21 (1), 4187 -.
DOI: 10.1038/srep19726
HAL: hal-01413169v1
2015
Cindy J. Castelle, Magali Roger, Marielle Bauzan, Myriam Brugna, Sabrina Lignon, Manfred Nimtz, Olga V. Golyshina, Marie-Thérèse Giudici-Orticoni, Marianne Guiral.
The aerobic respiratory chain of the acidophilic archaeon Ferroplasma acidiphilum : A membrane-bound complex oxidizing ferrous iron.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2015, 1847 (8), 717 - 728.
DOI: 10.1016/j.bbabio.2015.04.006
HAL: hal-01429900v1
2014
Sébastien Le Laz, Arlette Kpebe, Marielle Bauzan, Sabrina Lignon, Marc Rousset, Myriam Brugna.
A Biochemical Approach to Study the Role of the Terminal Oxidases in Aerobic Respiration in Shewanella oneidensis MR-1.
PLoS ONE, 2014, 172 (1), 6557 -.
DOI: 10.1371/journal.pone.0086343
HAL: hal-01494488v1
Sébastien Le Laz, Arlette Kpebe, Jean Lorquin, Myriam Brugna, Marc Rousset.
H2-dependent azoreduction by Shewanella oneidensis MR-1: involvement of secreted flavins and both [Ni–Fe] and [Fe–Fe] hydrogenases.
Appl Microbiol Biotechnol, 2014, 73 (6), 7759 - 2707.
DOI: 10.1007/s00253-013-5208-z
HAL: hal-01494493v1
2011
Pierre-Pol Liebgott, Antonio L. de Lacey, Bénédicte Burlat, Laurent Cournac, Pierre Richaud, Myriam Brugna, Victor M. Fernandez, Bruno Guigliarelli, Marc Rousset, Christophe Léger, Sébastien Dementin.
Original Design of an Oxygen-Tolerant [NiFe] Hydrogenase: Major Effect of a Valine-to-Cysteine Mutation near the Active Site.
J. Am. Chem. Soc., 2011, 133 (4), 986 - 997.
DOI: 10.1021/ja108787s
HAL: hal-01977599v1
2010
Laurence Prunetti, Pascale Infossi, Myriam Brugna, Christine Ebel, Marie-Thérèse Giudici-Orticoni, Marianne Guiral.
New Functional Sulfide Oxidase-Oxygen Reductase Supercomplex in the Membrane of the Hyperthermophilic Bacterium Aquifex aeolicus.
J. Biol. Chem., 2010, 12 (53), 205 - 41826.
DOI: 10.1074/jbc.M110.167841
Pascale Infossi, Elisabeth Lojou, Jean-Paul Chauvin, Gaetan Herbette, Myriam Brugna, Marie-Thérèse Giudici-Orticoni.
Aquifex aeolicus membrane hydrogenase for hydrogen biooxidation: Role of lipids and physiological partners in enzyme stability and activity.
International Journal of Hydrogen Energy, 2010, 35 (19), 10778 - 10789.
DOI: 10.1016/j.ijhydene.2010.02.054
HAL: hal-00686860v1
2009
Xiaojun Luo, Myriam Brugna, Pascale Tron-Infossi, Marie Thérèse Giudici-Orticoni, Élisabeth Lojou.
Immobilization of the hyperthermophilic hydrogenase from Aquifex aeolicus bacterium onto gold and carbon nanotube electrodes for efficient H2 oxidation.
J Biol Inorg Chem, 2009, 14 (8), 1275 - 1288.
DOI: 10.1007/s00775-009-0572-y
2008
Cindy Castelle, Marianne Guiral, Guillaume Malarte, Fouzia Ledgham, Gisèle Leroy, Myriam Brugna, Marie-Thérèse Giudici-Orticoni.
A New Iron-oxidizing/O 2 -reducing Supercomplex Spanning Both Inner and Outer Membranes, Isolated from the Extreme Acidophile Acidithiobacillus ferrooxidans.
J. Biol. Chem., 2008, 283 (38), 25803 - 25811.
DOI: 10.1074/jbc.M802496200
É. Lojou, X. Luo, M. Brugna, N. Candoni, S. Dementin, M. T. Giudici-Orticoni.
Biocatalysts for fuel cells: efficient hydrogenase orientation for H2 oxidation at electrodes modified with carbon nanotubes.
J Biol Inorg Chem, 2008, 13 (7), 1157 - 1167.
DOI: 10.1007/s00775-008-0401-8
HAL: hal-00335503
2006
Evelyne Lebrun, Joanne M. Santini, Myriam Brugna, Anne-Lise Ducluzeau, Soufian Ouchane, Barbara Schoepp-Cothenet, Frauke Baymann, Wolfgang Nitschke.
The Rieske Protein: A Case Study on the Pitfalls of Multiple Sequence Alignments and Phylogenetic Reconstruction.
2006, 23 (6), 1180 - 1191.
DOI: 10.1093/molbev/msk010
HAL: hal-00132690v1
2003
E. Lebrun, M. Brugna, F. Baymann, D. Muller, D. Lievremont, M.-C. Lett, W. Nitschke.
Arsenite Oxidase, an Ancient Bioenergetic Enzyme.
2003, 20 (5), 686 - 693.
DOI: 10.1093/molbev/msg071
HAL: hal-00113712v1
Frauke Baymann, Evelyne Lebrun, Myriam Brugna, Barbara Schoepp–Cothenet, Marie–Thérèse Giudici–Orticoni, Wolfgang Nitschke.
The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes.
Phil. Trans. R. Soc. Lond. B, 2003, 180 (1429), 1460 - 274.
DOI: 10.1098/rstb.2002.1184
HAL: hal-00343715v1
2001
Frauke Baymann, Myriam Brugna, Ulrich Mühlenhoff, Wolfgang Nitschke.
Daddy, where did (PS)I come from?.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001, 1507 (1-3), 291 - 310.
DOI: 10.1016/S0005-2728(01)00209-2
Barbara Schoepp-Cothenet, Michael Schütz, Frauke Baymann, Myriam Brugna, Wolfgang Nitschke, Hannu Myllykallio, Christian Schmidt.
The membrane-extrinsic domain of cytochrome b 558/566 from the Archaeon Sulfolobus acidocaldarius performs pivoting movements with respect to the membrane surface.
2001, 16 (3), 544 - 376.
DOI: 10.1016/S0014-5793(00)02357-7
2000
Michael Schütz, Myriam Brugna, Evelyne Lebrun, Frauke Baymann, Robert Huber, Karl-Otto Stetter, Günter Hauska, René Toci, Danielle Lemesle-Meunier, Pascale Tron, Christian Schmidt, Wolfgang Nitschke.
Early Evolution of Cytochrome bc Complexes.
Journal of Molecular Biology, 2000, 300 (4), 663 - 675.
DOI: 10.1006/jmbi.2000.3915
M. Brugna, S. Rodgers, A. Schricker, G. Montoya, M. Kazmeier, W. Nitschke, I. Sinning.
A spectroscopic method for observing the domain movement of the Rieske iron-sulfur protein.
Proceedings of the National Academy of Sciences, 2000, 1275 (1-2), 54 - 2074.
DOI: 10.1073/pnas.030539897
1999
Myriam Brugna, Wolfgang Nitschke, Marcel Asso, Bruno Guigliarelli, Danielle Lemesle-Meunier, Christian Schmidt.
Redox Components of Cytochrome bc -type Enzymes in Acidophilic Prokaryotes.
J. Biol. Chem., 1999, 274 (24), 16766 - 16772.
DOI: 10.1074/jbc.274.24.16766
Barbara Schoepp, Myriam Brugna, Astrid Riedel, Wolfgang Nitschke, David M. Kramer.
The Q o -site inhibitor DBMIB favours the proximal position of the chloroplast Rieske protein and induces a p K -shift of the redox-linked proton.
1999, 112 (3), 535 - 250.
DOI: 10.1016/S0014-5793(99)00511-6