Chargée de Recherche, CNRS
+33 4 91 16 46 10
Equipe / Group: BIP 01
I am interested in bacterial metabolisms, in particular how bacteria can adapt to several substrates to sustain growth in changing environments. During my PhD, I focused on the characterization of the molecular actors (metalloenzyme) of bacterial metabolism using biochemical, biophysical and structural approaches. During my first postdoc (Sargent Lab, UK), I have been interested into the hydrogen (H2) metabolism of Escherichia coli. My objective was to rewire E. coli for carbon dioxide (CO2) fixation using H2 as energy source, something which is not expected by the bacteria in Nature. Using synthetic biology combined with chemical engineering, I designed an efficient laboratory-scale bioprocess for the conversion of CO2 into valuable chemicals. Keeping with this research continuum, I joined the BIP laboratory (Giudici Lab) for a second postdoc which aimed at deciphering the metabolic interactions network between two bacteria involved in the process of microbial bio-H2 production using cell biology and quantitative proteomic approaches. Following my recruitment in 2022, I am now trying to unveil the molecular basis of bacterial cooperation by developing new ecological models. In particular, I am currently interested in the role of quorum sensing in triggering bacterial interactions and its link with the metabolic activity of microbial communities.
Publications
ORCID id: https://orcid.org/0000-0001-9696-2762.
2024
Magali Roger, Philippe Leone, Ninian J. Blackburn, Sam Horrell, Tadeo Moreno Chicano, Frédéric Biaso, Marie-Thérèse Giudici-Orticoni, Luciano A. Abriata, Greg L. Hura, Michael A. Hough, Giuliano Sciara, Marianne Ilbert.
Beyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features.
Dalton Trans., 2024, - .
DOI: 10.1039/d3dt03372d
HAL: hal-04386843v1
2023
Tetyana Kyrpel, Vita Saska, Anne de Poulpiquet, Mathieu Luglia, Audrey Soric, Magali Roger, Oksana Tananaiko, Marie Thérèse Giudici-Orticoni, Elisabeth Lojou, Ievgen Mazurenko.
Hydrogenase-based electrode for hydrogen sensing in a fermentation bioreactor.
Biosensors and Bioelectronics, 2023, 225, 115106.
DOI: 10.1016/j.bios.2023.115106
HAL: hal-03963086
2022
Magali Roger, Xavier Marbehan, Pascale Infossi, Louis Delecourt, Cassandra Backes, Stéphane Delaunay, Marie-Thérèse Giudici-Orticoni.
Deciphering nutrient cross-feeding interaction network in an artificial bacterial consortium.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2022, 1863, 148824 -.
DOI: 10.1016/j.bbabio.2022.148824
HAL: hal-03846172v1
Louis Delecourt, Magali Roger, Pascale Infossi, Christophe Bordi, Marie-Thérèse Giudici-Orticoni.
Unravelling the molecular basis of metabolic interactions in synthetic consortia dedicated for bio-H2 production.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2022, 1863, 148825 -.
DOI: 10.1016/j.bbabio.2022.148825
HAL: hal-03846181v1
Magali Roger, Philippe Leone, Ninan Blackburn, Sam Horrell, Tadeo Moreno Chicano, Marie-Thérèse Giudici-Orticoni, Luciano A. Abriata, Greg L. Hura, Michael A. Hough, Giulano Sciara, Marianne Ilbert.
Three-dimensional structure of the single domain cupredoxin AcoP.
2022.
DOI: 10.1101/2022.03.21.484586
2021
Magali Roger, Thomas C. P. Reed, Frank Sargent.
Harnessing Escherichia coli for Bio-Based Production of Formate under Pressurized H 2 and CO 2 Gases.
Appl Environ Microbiol, 2021, 87 (21).
DOI: 10.1128/AEM.00299-21
2019
Xie Wang, Romain Clément, Magali Roger, Marielle Bauzan, Ievgen Mazurenko, Anne de Poulpiquet, Marianne Ilbert, Elisabeth Lojou.
Bacterial Respiratory Chain Diversity Reveals a Cytochrome c Oxidase Reducing O2 at Low Overpotentials.
J. Am. Chem. Soc., 2019, 141 (28), 11093 - 11102.
DOI: 10.1021/jacs.9b03268
HAL: hal-02160924v1
2018
Xie Wang, Magali Roger, Romain Clément, Sophie Lecomte, Frédéric Biaso, Luciano A. Abriata, Pascal Mansuelle, Ievgen Mazurenko, Marie-Thérèse Giudici-Orticoni, Elisabeth Lojou, Marianne Ilbert.
Electron transfer in an acidophilic bacterium: interaction between a diheme cytochrome and a cupredoxin.
Chem. Sci., 2018, 6 (21), 4879 - 4891.
DOI: 10.1039/C8SC01615A
HAL: hal-01793582v1
2017
Magali Roger, Giuliano Sciara, Frédéric Biaso, Elisabeth Lojou, Xie Wang, Marielle Bauzan, Marie-Thérèse Giudici-Orticoni, Alejandro J. Vila, Marianne Ilbert.
Impact of copper ligand mutations on a cupredoxin with a green copper center.
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017, 1858 (5), 351 - 359.
DOI: 10.1016/j.bbabio.2017.02.007
HAL: hal-01481398v1