member photo

Directrice de Recherche, CNRS

+33 4 91 16 45 49

Equipe / Group: BIP 02

We are interested in the proteins that regulate CO2 assimilation in microalgae and diatoms, and more specifically in Intrinsically disordered proteins (IDPs). These proteins are fascinating because they fulfill essential biological functions while lacking a stable ordered structure, whereas it was long thought that a well folded structure was an absolute prerequesite for the proper activity of proteins. Instead, they are highly dynamics and adopt a myriad of conformations in the cell. We now know that no less than 30% of the proteins encoded by eukaryotic genomes contain long disordered regions. They are often involved in multiple interactions fostered by their structural plasticity. Encounter with their partners is often accompanied by dramatic changes in the structure and dynamics of these IDPs.
We have developed an expertise in the study of these original proteins and of their mechanisms of action by combining a series of complementary biophysical techniques. We are in particular expert in Small Angle X-ray Scattering (SAXS) and Small Angle Neutron Scattering (SANS), two very powerful techniques that provide crucial information on the structural properties of flexible polypeptide chains and on their distribution of conformations. We use SAXS, in combination with data from X-ray crystallography, NMR, circular dichroism and molecular modelling, to assess the structure and dynamics of IDPs, when free in various solution conditions, and when they undergo large conformational changes upon interaction with their partner(s).

ORCID id: 0000-0002-7464-6192


Hélène Launay, Luisana Avilan, Cassy Gérard, Goetz Parsiegla, Véronique Receveur‐Brechot, Brigitte Gontero, Frédéric Carriere.
Location of the photosynthetic carbon metabolism in microcompartments and separated phases in microalgal cells.
FEBS Letters, 2023, - . DOI: 10.1002/1873-3468.14754 HAL: hal-04290010v1

Véronique Receveur-Bréchot.
AlphaFold, small-angle X-ray scattering and ensemble modelling: a winning combination for intrinsically disordered proteins.
J Appl Cryst, 2023, 56 (5), 1313 - 1314. DOI: 10.1107/S1600576723008403 HAL: hal-04284577v1


Cassy Gérard, Frédéric Carrière, Véronique Receveur-Bréchot, Hélène Launay, Brigitte Gontero.
A Trajectory of Discovery: Metabolic Regulation by the Conditionally Disordered Chloroplast Protein, CP12.
Biomolecules, 2022, 12 (8), 1047 -. DOI: 10.3390/biom12081047 HAL: hal-03747280


Hélène Launay, Véronique Receveur-Bréchot, Frédéric Carrière, Brigitte Gontero.
Protein disorder in algal metabolism.
Atlas of Science, 2021. (voir / see) HAL: hal-03326941

Erik L. Jensen, Véronique Receveur-Brechot, Mohand Hachemane, Laura Wils, Pascale Barbier, Goetz Parsiegla, Brigitte Gontero, Hélène Launay.
Structural Contour Map of the Iota Carbonic Anhydrase from the Diatom Thalassiosira pseudonana Using a Multiprong Approach.
IJMS, 2021, 22 (16), 8723 -. DOI: 10.3390/ijms22168723 HAL: hal-03321117v1

Helene Launay, Hui Shao, Olivier Bornet, Francois-Xavier Cantrelle, Regine Lebrun, Veronique Receveur-Brechot, Brigitte Gontero.
Flexibility of Oxidized and Reduced States of the Chloroplast Regulatory Protein CP12 in Isolation and in Cell Extracts.
Biomolecules, 2021, 11 (5), 701 -. DOI: 10.3390/biom11050701 HAL: hal-03194824

Hui Shao, Wenmin Huang, Luisana Avilan, Véronique Receveur-Bréchot, Carine Puppo, Rémy Puppo, Régine Lebrun, Brigitte Gontero, Hélène Launay.
A new type of flexible CP12 protein in the marine diatom Thalassiosira pseudonana.
Cell Commun Signal, 2021, 19 (1). DOI: 10.1186/s12964-021-00718-x HAL: hal-03194815


Hélène Launay, Véronique Receveur-Bréchot, Frédéric Carrière, Brigitte Gontero.
Orchestration of algal metabolism by protein disorder.
Archives of Biochemistry and Biophysics, 2019, 672, 108070 -. DOI: 10.1016/j.abb.2019.108070 HAL: hal-02266032v1


Hélène Launay, Patrick Barré, Carine Puppo, Yizhi Zhang, Stéphanie Maneville, Brigitte Gontero, Véronique Receveur-Bréchot.
Cryptic Disorder Out of Disorder: Encounter between Conditionally Disordered CP12 and Glyceraldehyde-3-Phosphate Dehydrogenase.
Journal of Molecular Biology, 2018, 430 (8), 1218 - 1234. DOI: 10.1016/j.jmb.2018.02.020 HAL: hal-01794097v1

Hélène Launay, Patrick Barré, Carine Puppo, Yizhi Zhang, Stéphanie Maneville, Brigitte Gontero, Véronique Receveur-Bréchot.
Cryptic Disorder Out of Disorder: Encounter between Conditionally Disordered CP12 and Glyceraldehyde-3-Phosphate Dehydrogenase.
Journal of Molecular Biology, 2018, 430 (8), 1218 - 1234. DOI: 10.1016/j.jmb.2018.02.020 HAL: hal-01794097v1


Aurelie Badillo, Véronique Receveur-Brechot, Stéphane Sarrazin, François-Xavier Cantrelle, Frédéric Delolme, Marie-Laure Fogeron, Jennifer Molle, Roland Montserret, Anja Bockmann, Ralf Bartenschlager, Volker Lohmann, Guy Lippens, Sylvie Ricard-Blum, Xavier Hanoulle, François Penin.
Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.
Biochemistry, 2017, 56 (24), 3029 - 3048. DOI: 10.1021/acs.biochem.7b00212 HAL: hal-01785410v1


Rodrigo Arias-Cartin, Pierre Ceccaldi, Barbara Schoepp-Cothenet, Klaudia Frick, Jean-Michel Blanc, Bruno Guigliarelli, Anne Walburger, Stéphane Grimaldi, Thorsten Friedrich, Véronique Receveur-Brechot, Axel Magalon.
Redox cofactors insertion in prokaryotic molybdoenzymes occurs via a conserved folding mechanism.
Sci Rep, 2016, 12 (1), 543. DOI: 10.1038/srep37743 HAL: hal-01415067v1

Hélène Launay, Patrick Barré, Carine Puppo, Stéphanie Manneville, Brigitte Gontero, Véronique Receveur-Bréchot.
Absence of residual structure in the intrinsically disordered regulatory protein CP12 in its reduced state.
Biochemical and Biophysical Research Communications, 2016, 477 (1), 20 - 26. DOI: 10.1016/j.bbrc.2016.06.014 HAL: hal-01430932v1

Shishir P. S. Chundawat, Chad D. Paavola, Babu Raman, Matthieu Nouailler, Suzanne L. Chan, Jonathan R. Mielenz, Veronique Receveur-Brechot, Jonathan D. Trent, Bruce E. Dale.
Saccharification of thermochemically pretreated cellulosic biomass using native and engineered cellulosomal enzyme systems.
React. Chem. Eng., 2016, 16 (5), 577 - 628. DOI: 10.1039/c6re00172f


Pierre Roblin, Pierre Lebrun, Prakash Rucktooa, Frederique Dewitte, Zoe Lens, Véronique Receveur-Brechot, Vincent Raussens, Vincent Villeret, Coralie Bompard.
The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners.
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013, 1834 (12), 2564 - 2572. DOI: 10.1016/j.bbapap.2013.09.014


Veronique Receveur-Brechot, Dominique Durand.
How Random are Intrinsically Disordered Proteins? A Small Angle Scattering Perspective.
CPPS, 2012, 13 (1), 55 - 75. DOI: 10.2174/138920312799277901

Mirjam Czjzek, Henri-Pierre Fierobe, Véronique Receveur-Bréchot.
Chapter ten - Small-Angle X-ray Scattering and Crystallography: A Winning Combination for Exploring the Multimodular Organization of Cellulolytic Macromolecular Complexes.
Methods in Enzymology, 2012, 510, 183 - 210. DOI: 10.1016/B978-0-12-415931-0.00010-0

Gary W. Daughdrill, Stepan Kashtanov, Amber Stancik, Shannon E. Hill, Gregory Helms, Martin Muschol, Véronique Receveur-Bréchot, F. Marty Ytreberg.
Understanding the structural ensembles of a highly extended disordered protein.
Mol. BioSyst., 2012, 19 (S3), 109 - 319. DOI: 10.1039/c1mb05243h


Virginie Moucadel, Renaud Prudent, Céline F. Sautel, Florence Teillet, Caroline Barette, Laurence Lafanechere, Veronique Receveur-Brechot, Claude Cochet.
Antitumoral activity of allosteric inhibitors of Protein kinase CK2.
Oncotarget, 2011, 2 (12). DOI: 10.18632/oncotarget.361

Eric Durand, Gabriel Waksman, Veronique Receveur-Brechot.
Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system.
BMC Structural Biology, 2011, 11 (1), 4 -. DOI: 10.1186/1472-6807-11-4

Anne-Laure Molinier, Matthieu Nouailler, Odile Valette, Chantal Tardif, Véronique Receveur-Bréchot, Henri-Pierre Fierobe.
Synergy, Structure and Conformational Flexibility of Hybrid Cellulosomes Displaying Various Inter-cohesins Linkers.
Journal of Molecular Biology, 2011, 405 (1), 143 - 157. DOI: 10.1016/j.jmb.2010.10.013


Marine Foucault, Katia Mayol, Véronique Receveur-Bréchot, Marie-Claire Bussat, Christine Klinguer-Hamour, Bernard Verrier, Alain Beck, Richard Haser, Patrice Gouet, Christophe Guillon.
UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate.
Proteins, 2009, 293, 321 - NA. DOI: 10.1002/prot.22661 HAL: hal-02121744v1


Guillaume K. Sonan, Véronique Receveur-Brechot, Colette Duez, Nushin Aghajari, Mirjam Czjzek, Richard Haser, Charles Gerday.
The linker region plays a key role in the adaptation to cold of the cellulase from an Antarctic bacterium.
2007, 22 (2), 4673 - 302. DOI: 10.1042/BJ20070640 HAL: hal-00478802v1


Guy Schoehn, Frédéric M. D. Vellieux, M. Asunción Durá, Véronique Receveur-Bréchot, Céline M. S. Fabry, Rob W. H. Ruigrok, Christine Ebel, Alain Roussel, Bruno Franzetti.
An Archaeal Peptidase Assembles into Two Different Quaternary Structures.
J. Biol. Chem., 2006, 40 (47), 7035 - 36337. DOI: 10.1074/jbc.M604417200 HAL: hal-00475651v1

Véronique Receveur-Bréchot, Mirjam Czjzek, Annick Barre, Alain Roussel, Willy J. Peumans, Els J.M. Van Damme, Pierre Rougé.
Crystal structure at 1.45-Å resolution of the major allergen endo-β-1,3-glucanase of banana as a molecular basis for the latex-fruit syndrome.
Proteins, 2006, 20 (1), 513 - 242. DOI: 10.1002/prot.20876 HAL: hal-00475655v1

Gross M, Receveur-Bréchot V.
Les protéines humaines.
La Recherche, Hors-Série « La biologie en 18 mots clés », 2006.

Véronique Receveur-Bréchot, Jean-Marie Bourhis, Vladimir N. Uversky, Bruno Canard, Sonia Longhi.
Assessing protein disorder and induced folding.
Proteins, 2006, 415 (Pt 12), 549 - 45. DOI: 10.1002/prot.20750


Michal Hammel, Henri-Pierre Fierobe, Mirjam Czjzek, Vandana Kurkal, Jeremy C. Smith, Edward A. Bayer, Stéphanie Finet, Véronique Receveur-Bréchot.
Structural Basis of Cellulosome Efficiency Explored by Small Angle X-ray Scattering.
Journal of Biological Chemistry, 2005, 280 (46), 38562 - 38568. DOI: 10.1074/jbc.M503168200

Jean‐Marie Bourhis, Véronique Receveur‐Bréchot, Michael Oglesbee, Xinsheng Zhang, Matthew Buccellato, Hervé Darbon, Bruno Canard, Stéphanie Finet, Sonia Longhi.
The intrinsically disordered C‐terminal domain of the measles virus nucleoprotein interacts with the C‐terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded.
Protein Science, 2005, 14 (8), 1975 - 1992. DOI: 10.1110/ps.051411805

Sébastien Violot, Nushin Aghajari, Mirjam Czjzek, Georges Feller, Guillaume K. Sonan, Patrice Gouet, Charles Gerday, Richard Haser, Véronique Receveur-Bréchot.
Structure of a Full Length Psychrophilic Cellulase from Pseudoalteromonas haloplanktis revealed by X-ray Diffraction and Small Angle X-ray Scattering.
Journal of Molecular Biology, 2005, 348 (5), 1211 - 1224. DOI: 10.1016/j.jmb.2005.03.026

Marc Graille, Cong-Zhao Zhou, Véronique Receveur-Bréchot, Bruno Collinet, Nathalie Declerck, Herman van Tilbeurgh.
Activation of the LicT Transcriptional Antiterminator Involves a Domain Swing/Lock Mechanism Provoking Massive Structural Changes.
Journal of Biological Chemistry, 2005, 280 (15), 14780 - 14789. DOI: 10.1074/jbc.M414642200

Ingemar von Ossowski, Julian T. Eaton, Mirjam Czjzek, Stephen J. Perkins, Torben P. Frandsen, Martin Schülein, Pierre Panine, Bernard Henrissat, Veronique Receveur-Bréchot.
Protein Disorder: Conformational Distribution of the Flexible Linker in a Chimeric Double Cellulase.
Biophysical Journal, 2005, 88 (4), 2823 - 2832. DOI: 10.1529/biophysj.104.050146

M. Asunción Durá, Veronique Receveur-Brechot, Jean-Pierre Andrieu, Christine Ebel, Guy Schoehn, Alain Roussel, Bruno Franzetti.
Characterization of a TET-like Aminopeptidase Complex from the Hyperthermophilic Archaeon Pyrococcus horikoshii.
Biochemistry, 2005, 44 (9), 3477 - 3486. DOI: 10.1021/bi047736j

Sophie Porciero, Véronique Receveur-Bréchot, Kazushige Mori, Bruno Franzetti, Alain Roussel.
Expression, purification, crystallization and preliminary crystallographic analysis of a deblocking aminopeptidase from Pyrococcus horikoshii.
Acta Cryst Sect F Struct Biol Cryst Commun, 2005, 61 (2), 239 - 242. DOI: 10.1107/S1744309105001910

Receveur-Bréchot V, Karlin D.
Le désordre, clé de voûte des protéines.
La Recherche, 2005.


Michal Hammel, Henri-Pierre Fierobe, Mirjam Czjzek, Stéphanie Finet, Véronique Receveur-Bréchot.
Structural Insights into the Mechanism of Formation of Cellulosomes Probed by Small Angle X-ray Scattering.
Journal of Biological Chemistry, 2004, 279 (53), 55985 - 55994. DOI: 10.1074/jbc.M408979200

Jean-Marie Bourhis, Kenth Johansson, Véronique Receveur-Bréchot, Christopher J. Oldfield, Keith A. Dunker, Bruno Canard, Sonia Longhi.
The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner.
Virus Research, 2004, 99 (2), 157 - 167. DOI: 10.1016/j.virusres.2003.11.007

Receveur-Bréchot V, Gross M.
Protéines de stress au front contre le cancer..
Biofutur, 2004, 244 (13).


Cosma D Dellisanti, Silvia Spinelli, Christian Cambillau, John B.C Findlay, Peter F Zagalsky, Stéphanie Finet, Véronique Receveur-Bréchot.
Quaternary structure of alpha‐crustacyanin from lobster as seen by small‐angle X‐ray scattering.
FEBS Letters, 2003, 544 (1-3), 189 - 193. DOI: 10.1016/s0014-5793(03)00486-1

Sonia Longhi, Véronique Receveur-Bréchot, David Karlin, Kenth Johansson, Hervé Darbon, David Bhella, Robert Yeo, Stéphanie Finet, Bruno Canard.
The C-terminal Domain of the Measles Virus Nucleoprotein Is Intrinsically Disordered and Folds upon Binding to the C-terminal Moiety of the Phosphoprotein.
Journal of Biological Chemistry, 2003, 278 (20), 18638 - 18648. DOI: 10.1074/jbc.M300518200


Véronique Receveur, Mirjam Czjzek, Martin Schülein, Pierre Panine, Bernard Henrissat.
Dimension, Shape, and Conformational Flexibility of a Two Domain Fungal Cellulase in Solution Probed by Small Angle X-ray Scattering.
Journal of Biological Chemistry, 2002, 277 (43), 40887 - 40892. DOI: 10.1074/jbc.M205404200

David Karlin, Sonia Longhi, Véronique Receveur, Bruno Canard.
The N-Terminal Domain of the Phosphoprotein of Morbilliviruses Belongs to the Natively Unfolded Class of Proteins.
Virology, 2002, 296 (2), 251 - 262. DOI: 10.1006/viro.2001.1296


Aaron K. Chamberlain, Veronique Receveur, Andrew Spencer, Christina Redfield, Christopher M. Dobson.
Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
Protein Science, 2001, 10 (12), 2525 - 2530. DOI: 10.1110/ps.28101

Nathalie Declerck, Hélène Dutartre, Véronique Receveur, Virginie Dubois, Catherine Royer, Stéphane Aymerich, Herman van Tilbeurgh.
Dimer stabilization upon activation of the transcriptional antiterminator LicT 1 1Edited by T. Richmond.
Journal of Molecular Biology, 2001, 314 (4), 671 - 681. DOI: 10.1006/jmbi.2001.5185


Ludmilla A. Morozova-Roche, Jesús Zurdo, Andrew Spencer, Wim Noppe, Veronique Receveur, David B. Archer, Marcel Joniau, Christopher M. Dobson.
Amyloid Fibril Formation and Seeding by Wild-Type Human Lysozyme and Its Disease-Related Mutational Variants.
Journal of Structural Biology, 2000, 130 (2-3), 339 - 351. DOI: 10.1006/jsbi.2000.4264

Veronique Receveur, Pascal Garcia, Dominique Durand, Patrice Vachette, Michel Desmadril.
Role of hydrophobic interactions in yeast phosphoglycerate kinase stability.
Proteins, 2000, 38 (2), 226 - 238. DOI: 10.1002/(sici)1097-0134(20000201)38:23.0.co;2-h

Andrei-José Petrescu, Patrick Calmettes, Dominique Durand, Veronique Receveur, Jeremy C. Smith.
Change in backbone torsion angle distribution on protein folding.
Protein Sci., 2000, 9 (6), 1129 - 1136. DOI: 10.1110/ps.9.6.1129

Gross M, Receveur V.
Les protéines humaines.
La Recherche, 2000.


Deborah K. Wilkins, Shaun B. Grimshaw, Véronique Receveur, Christopher M. Dobson, Jonathan A. Jones, Lorna J. Smith.
Hydrodynamic Radii of Native and Denatured Proteins Measured by Pulse Field Gradient NMR Techniques.
Biochemistry, 1999, 38 (50), 16424 - 16431. DOI: 10.1021/bi991765q

Gross M, Receveur V.
Le repliement raté des protéines.
La Recherche, 1999.


Andrei-Jose Peterscu, Veronique Receveur, Patrick Calmettes, Dominique Durand, Jeremy C. Smith.
Excluded volume in the configurational distribution of a strongly-denatured protein.
Protein Sci., 1998, 7 (6), 1396 - 1403. DOI: 10.1002/pro.5560070616

Pascal Garcia, Fabienne Mérola, Véronique Receveur, Patrick Blandin, Philippe Minard, Michel Desmadril.
Steady State and Time-Resolved Fluorescence Study of Residual Structures in an Unfolded Form of Yeast Phosphoglycerate Kinase.
Biochemistry, 1998, 37 (20), 7444 - 7455. DOI: 10.1021/bi973161x

Véronique Receveur, Dominique Durand, Michel Desmadril, Patrick Calmettes.
Repulsive interparticle interactions in a denatured protein solution revealed by small angle neutron scattering.
FEBS Letters, 1998, 426 (1), 57 - 61. DOI: 10.1016/s0014-5793(98)00309-3


Véronique Receveur, Patrick Calmettes, Jeremy C Smith, Michel Desmadril, Geritt Coddens, Dominique Durand,.
Picosecond dynamical changes on denaturation of yeast phosphoglycerate kinase revealed by quasielastic neutron scattering.
Proteins, 1997, 28 (3), 380 387.

A.J. Petrescu, V. Receveur, P. Calmettes, D. Durand, M. Desmadril, B. Roux, J.C. Smith.
Small-angle neutron scattering by a strongly denatured protein: analysis using random polymer theory.
Biophysical Journal, 1997, 72 (1), 335 - 342. DOI: 10.1016/S0006-3495(97)78672-7